POWERFUL
Eliminates pain1
Real UBRELVY patient.
WHEN HEAD PAIN SPIKES
Eliminates pain1
21% of patients experienced pain freedom at 2 hours (co-primary endpoint)*
UBRELVY 100 mg (95/448) vs 12% placebo (54/456)1,3
Relieves pain quickly1
61% of patients experienced pain relief at 2 hours (secondary endpoint)*
UBRELVY 100 mg (275/448) vs 49% placebo (224/456)1,4
BEFORE HEAD PAIN STRIKES
UBRELVY has demonstrated prodrome data for treatment early in the migraine attack from a phase 3 clinical trial5
Data on patients who avoided moderate to severe headache pain, when UBRELVY 100 mg was taken during prodrome5
*In pivotal clinical studies, patients took UBRELVY within 4 hours of migraine headache onset.6
†The prodrome study was a phase 3, multicenter, randomized, double-blind, placebo-controlled, crossover study in which the prodrome phase was defined as 1-6 hours prior to onset of headache.5 For additional details, see prodrome study design pop-up above.
Data presented above are in reference to UBRELVY 100 mg only. See similar results for patients taking UBRELVY 50 mg.7
See ACHIEVE pivotal trials design pop-up above for more details, including additional co-primary endpoint data.
‡Managed Markets Insight & Technology, LLCTM, a trademark of MMIT. Data as of December 2024 and subject to change.
Data are not a guarantee of coverage, or partial or full payment, by any payers listed. Actual benefits are determined by respective plan administrators. Insurer plans, coverage criteria, and formularies are subject to change without notice. Check each patient’s coverage with applicable insurer. AbbVie does not endorse any individual plans. Formulary coverage does not imply efficacy or safety.
§Unrestricted implies no step edit.
IIEligibility: Available to patients with commercial insurance coverage for UBRELVY who meet eligibility criteria. This copay assistance program is not available to patients receiving prescription reimbursement under any federal, state, or government-funded insurance programs (for example, Medicare [including Part D], Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs), or where prohibited by law. Offer subject to change or termination without notice. Restrictions, including monthly maximums, may apply. This is not health insurance. For full Terms and Conditions, visit UBRELVY.com/savings-terms or call 1-844-482-7358 for additional information. To learn about AbbVie’s privacy practices and your privacy choices, visit https://abbv.ie/corpprivacy.
CONTRAINDICATIONS
UBRELVY is contraindicated:
Hypersensitivity Reactions: Cases, including anaphylaxis, dyspnea, facial or throat edema, rash, urticaria, and pruritus, have been reported. Hypersensitivity reactions can occur minutes, hours, or days after administration. Most reactions were not serious, and some led to discontinuation. If a serious or severe reaction occurs, discontinue UBRELVY and institute appropriate therapy.
Hypertension (HTN): Development or worsening of pre-existing HTN has been reported following the use of CGRP antagonists, including UBRELVY. Some patients who developed new-onset HTN had risk factors. There were cases requiring initiation of HTN treatment and, in some cases, hospitalization. HTN may occur at any time but was most frequently reported within 7 days of initiation. The CGRP antagonist was discontinued in many of the cases. Monitor patients for new-onset or worsening of pre-existing HTN and consider whether discontinuation of UBRELVY is warranted if evaluation fails to establish an alternative etiology or blood pressure is inadequately controlled.
Raynaud’s phenomenon (RP): Development, recurrence, or worsening of pre-existing RP has been reported following the use of CGRP antagonists, including UBRELVY. In cases with small molecule CGRP antagonists, symptom onset occurred a median of 1.5 days following dosing. Many of the cases reported serious outcomes, including hospitalizations and disability, generally related to debilitating pain. In most cases, discontinuation of the CGRP antagonist resulted in resolution of symptoms. UBRELVY should be discontinued if signs or symptoms of RP develop, and patients should be evaluated by a healthcare provider if symptoms do not resolve. Patients with a history of RP should be monitored for, and informed about the possibility of, worsening or recurrence of signs and symptoms.
ADVERSE REACTIONS
The most common adverse reactions were nausea (4% vs 2% placebo) and somnolence (3% vs 1% placebo).
DRUG INTERACTIONS
UBRELVY® (ubrogepant) is indicated for the acute treatment of migraine with or without aura in adults. UBRELVY is not indicated for the preventive treatment of migraine.
US-UBR-250101
References: 1. UBRELVY [package insert]. North Chicago, IL: AbbVie Inc.; 2025. 2. Retail weekly prescription data from IQVIA as of 03/25. 3. Data on file. AbbVie Inc. 4. Dodick DW, Lipton RB, Ailani J, et al. Ubrogepant for the treatment of migraine. N Engl J Med. 2019;381(23):2230-2241. 5. Dodick DW, Goadsby PJ, Schwedt TJ, et al. Ubrogepant for the treatment of migraine attacks during the prodrome: a phase 3, multicentre, randomised, double-blind, placebo-controlled, crossover trial in the USA. Lancet. 2023;402(10419):2307-2316. 6. Dodick DW, Lipton RB, Ailani J, et al. Ubrogepant, an acute treatment for migraine, improved patient-reported functional disability and satisfaction in 2 single-attack phase 3 randomized trials, ACHIEVE I and II. Headache. 2020;60(4):686-700. 7. Hutchinson S, Dodick DW, Treppendahl C, et al. Ubrogepant for the acute treatment of migraine: pooled efficacy, safety, and tolerability from the ACHIEVE I and ACHIEVE II phase 3 randomized trials. Neurol Ther. 2021;10(1):235-249.